Mihajlo D. Mesarovic (1928), (Serbian: Mihajlo D. Mesarović, Serbian Cyrillic: Михајло Д. Месаровић) is a Yugoslavian scientist, who is a professor of Systems Engineering and Mathematics at Case Western Reserve University. Mesarovic was pioneer in the field of systems theory, he was UNESCO Scientific Advisor on Global change and also a member of the Club of Rome.